RNA Details
Disease Name
liver cirrhosis
Tissue
liver
RNA Symbol
mir-29b-1
RNA ID
RNA Type
miRNA
Alteration Pattern
dna methylation;down regelation
Species
mus musculus
Detection Methods
qRT-PCR; dual-lucimmunofluorescenceerase reporter assay etc.
Target
PTEN
Pathway
PTEN
PubMed ID
Title
Curcumin up-regulates phosphatase and tensin homologue deleted on chromosome 10 through microRNA-mediated control of DNA methylation--a novel mechanism suppressing liver fibrosis
Year
2014
Function
Dna methylation and mecp2 may provide molecular mechanisms for silencing of ptch1.
RNA Details
Disease Name
liver cirrhosis
Tissue
liver
RNA Symbol
mir-29b-1
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
qRT-PCR; dual-lucimmunofluorescenceerase reporter assay etc.
Target
NA
Pathway
PTEN
PubMed ID
Title
Curcumin up-regulates phosphatase and tensin homologue deleted on chromosome 10 through microRNA-mediated control of DNA methylation--a novel mechanism suppressing liver fibrosis
Year
2014
Function
Sept9 contributed to alleviate liver fibrosis might partially through promoting activated hscs apoptosis and this anti-fibrogenesis effect might be blocked by dnmt-3a mediated methylation of sept9.